Recordings

10th Annual Meeting Presentations

1. ENRICH Plus Furthering the Science – Neuroprotective Agent Trial in ICH
   J. Marc Simard, MD at University of Maryland School of Medicine
2. ENRICH Trial – Study Design, Trial Results & Next Steps
   Gustavo Pradilla, MD at Emory University School of Medicine
3. Functional Precision Medicine Clinical Paradigm for High Grade Glioma
   Analiz Rodriguez, MD, PhD at UAMS
4. How the Neurosurgeon Uniquely Meets the Unmet Need in Today’s Precision Medicine Era
   Henry Brem, MD at Johns Hopkins Medicine
5. Personalized Brain Mapping
   Michael Sughrue, MD – Prince of Wales Hospital, Australia
6. Focused Ultrasound & the Future of Neurosurgery
   Nir Lipsman, MD, PhD at Sunnybrook Health Sciences Centre, Toronto
7. Laser Interstitial Thermal Therapy – A MIS Approach to Primary & Secondary Brain Tumors
   Gene Barnett, MD at Cleveland Clinic
8. BrainPath Exoscope Use in Pediatric Neurosurgery – Outcomes & Novel Uses Outside the Head
   Ramin Eskandari, MD at The Medical University of South Carolina – Shawn Jenkins Children’s Hospital
9. Fully Implanted Endovascular Brain Computer Interface
   J. Mocco, MD at Icahn School of Medicine at Mount Sinai
10. The Use of GammaTile Brachytherapy in the Treatment of Upfront & Recurrent Brain Tumors
    Jay McCracken, MD at Piedmont Atlanta Hospital
11. Immediate Biological Preservation of Tumor & Advanced Organoid Development for Oncology Analysis
    Tomas Garzon-Muvdi, MD, MSc at Emory University School of Medicine
12. An Overview of the Opportunities & Barriers in BCI
    Julian Bailes, MD at NorthShore University Health System
13. Use of Tubular Retractors to Access Deep Brain Lesions – The Johns Hopkins Experience
    Raj Mukherjee, MD, MPH at Johns Hopkins Medical Institutions
14. MIPS for Primary Brain Tumor – 2 Year Series at Kings Hospital
    Christos Soumpasis, MD at Emory University School of Medicine
15. MIPS Approach to Primary and Secondary Tumors vs Conventional – Is there a Difference?
    Justin Singer, MD at Spectrum Health
16. Neuroendoscopic Lavage
    Erin Kiehna, MD at Novant Health
17. Improving Neurosurgical Outcomes by Leveraging the Power of AI
    Daniel Donoho, MD at George Washington University School of Medicine and Health Sciences

9th Annual Meeting Presentations

1. ENRICH – A 300 Patient Randomized Controlled Trial Progress Report
   Gustavo Pradilla, MD at Emory University School of Medicine
2. INVEST/MIND/MIRROR/EVACUATE/MINUTE – Endoscopic & Surgiscopic ICH Trials
   Christopher Kellner, MD at Mount Sinai
3. 5-ALA Fluorescence-Guided Surgery and Intraoperative Photodynamic Therapy for Gliomas
   Constantinos Hadjipanayis, MD, PhD at Mount Sinai
4. Solving Neuro-Oncology Problems in the OR via Intra-Op Tissue Collection w/ Biological Preservation
   Arabinda Das, PhD – Medical University of South Carolina
5. Optimizing MIPS through the Lens of Connectomics
   Michael Sughrue, MD – Prince of Wales Hospital, Australia
6. The Debate on MIPS for Traumatic ICH
   Jefferson Chen, MD, PhD – UCI Health
7. Gammatile Therapy for Recurrent Glioblastomas – Potential Synergy with MI Neurosurgery
   Clark Chen, MD, PhD – University of Minnesota Medical School
8. Edema-Invariant White Matter Tractography in Precision Neurosurgery
   Sebastian Koga, MD – Ochsner Neuroscience Institute, New Orleans, University of Queensland (AU)
9. Biomarker Identification in Hemorrhagic Stroke
   Jay Lusk – Duke University
10. Can Proximity of Excitation Light Improve Differentiation between Normal Parenchyma & Tumor Boundary
    Martin G Young, DVM, DACVIM
11. Awake Craniotomy Tips & Technique
    Ronald Young II, MD – Delray Medical Center
12. Pre-Clinical Advancements, Subcortical Chip Implantation in Rodents – A Feasibility Milestone
    Julian Bailes, MD – NorthShore University Health System
13. Use of Ultrasound in MIPS for Real-Time Visualization
    Edward Duckworth, MD – St Luke’s Medical Center
14. Straight Talk on Complications – What can go Wrong
    Zachary Litvack, MD – Swedish Neuroscience Institute
    Panel Members include: Julian Bailes, MD at NorthShore University HealthSystem; Gustavo Pradilla, MD at Emory University School of Medicine; Justin Singer, MD at Spectrum Health and Ronald Young II, MD at Delray Medical Center.
15. Vascular Indications & Case Selection for MIPS with Emerging Technology
    Justin Singer, MD – Spectrum Health
16. ENRICH Plus: Building on What We have Learned – A Neuroprotective Agent ICH Trial
    J. Marc Simard, MD – University of Maryland School of Medicine
17. New Paradigm Brain Tumor Models for Serial Interrogation of Disease Progression & Therapy Evaluation
    Safwan Alomari, MD – Johns Hopkins Medicine
18. Molecular Biobanking Begins in the Operating Room – Role of the Neurosurgeon
    Analiz Rodriguez, MD, PhD – UAMS Health
19. Spatially-Registered Sampling to Elucidate Intra-Tumor Heterogeneity of the GBM Immune Landscape
    Dionysios Watson, MD, PhD – Cleveland Clinic
20. Surgical Applications – Improving our Understanding of GBM through Biological Tissue Preservation
    Alireza Mohammadi, MD – Cleveland Clinic
21. Maximal Safe GTR of Primary Brain Tumors in Eloquent Locations
    Kaisorn Chaichana, MD – Mayo Clinic
22. Tissue is the Issue in the Molecular Era: How the Neurosurgeon Uniquely Meets the Unmet Need
    Henry Brem, MD – Johns Hopkins Medicine
23. MIPS – Who and Where in the Neuro-Oncology Landscape
    Ranjeev Bhangoo, MD – Kings Hospital, London

Modern Neurosurgery for the Molecular Era

Join the Subcortical Surgery Group for 2 transformative presentations on the rapidly progressing molecular era of modern neurosurgery

• Evolving Neurosurgical role in the advancement of precision medicine starting in the OR
• Explore a unique mouse Avatar program and how neurosurgery and neuro oncology can partner in the development of personalized novel therapeutics

Presenters

1. The New OR: Tumor Neurosurgery in the Era of Precision Medicine Analiz Rodriguez, MD, PhD
2. Clinical Applications of Data from Treatment of Patient Derived Xenographs – a Mouse “Avatar” Program Lawrence Dickinson, MD

Brain Computer Interface – The Future Frontier of Neurosurgery

Join the Subcortical Surgery Group for the first ever BCI neurosurgeon focused webinar. The webinar will focus on education, discussion and collaboration around BCI. Join the conversation with our impressive faculty that have accomplished:

• First to implant BCI chips in the subcortical region of the brain
• BCI for restoration of communication and motor function
• First FDA approved device for BCI
• First approved FDA trial for BCI

Agenda

1. The Potential of Brain Computer Interface: Lots to Do Below the Surface – Subcortical Applications Julian Bailes, MD – NorthShore University HealthSystem
2. BCI for Restoration of Communication and Motor Function Jaimie Henderson, MD – Stanford Medicine
3. Neurolutions: A Brain Computer Interface Solution for Stroke Eric C. Leuthardt, MD, FNAI – Neurolutions
4. Sub, Sub, SubCortical Surgery: Transvascular BCI J Mocco, MD – synchron

Informing Neurosurgical Disconnections with Connectomics – 2 Part Series

Presenter – Michael Sughrue, MD – Prince of Wales Hospital

The field of connectomics has vastly updated our understanding of neurological anatomy, especially in identifying critical brain network structures that facilitate neurological processes. Such information is crucial for neurosurgeons to inform surgical decision-making. This two-part course explores eight surgical disconnections and trajectories, and how to practically use connectomic information to inform surgical planning. Teaching is conducted through hands-on application of connectomic software and detailed lab exercises.

• Review updates to neuroanatomy as informed by connectomics
• Explore lesions in eight regions of the brain and trajectories and approaches to perform disconnections
• Utilize connectomic software to improve neurosurgical planning

Part I:

Part II:

Immunotherapy and Newly Diagnosed GBM: Phase 1B Results and 2b Trial Overview Intraoperative Tissue Management as the Key to Improving Cell Viability

Presenter – David W. Andrews, MD

Special Look at Phase 1b Imvax Study to Assess the Safety & Efficacy of IGV-001

• Explore highest exposure cohort yielded significantly higher pro- inflammatory cytokine serum levels significant improvement in both PFS and OS over historical controls
• Study methylated subgroup manifesting a 3-fold improvement in mPFS with mOS not yet reached
• Deep dive with data lock, highest exposure cohort exhibiting significant improvement in both PFS and OS over historical controls

An Overview of Emerging Therapeutic Targets

• Examine the current treatment options and emerging targeted therapies
• If targeted therapies show limited efficacy as single agents, can the combination of several targeted therapies be of benefit to GBM patients?
• Additional research is urgently required to identify therapeutic targets in GBM: How can the industry design novel therapeutic strategies for the treatment of GBM?

Webinar Series – Tissue Management Intraoperatively

Presenters

Paul Gardner, MD
Peter J. Jannetta Professor Executive Vice Chair,
Surgical Services Neurosurgical Director,
Center for Cranial Base Surgery Director,
Surgical Neuroanatomy Lab University of Pittsburgh Dept of Neurological Surgery

Manmeet Ahluwalia, MD, MBA
Deputy Director,
Chief Scientific Officer and Chief of Solid Tumor Medical Oncology Miami Cancer Institute,
Baptist Health South Florida

Biological Tissue Collection & Preservation in Skull Base and Chordoma Surgery: Clinical & Research Value

This webinar will cover the use of intraoperative tissue collection in skull base disease, discussing value for both clinical and research applications. Addressing the challenges of skull base surgery with respect to difficult to reach locations and prevention of tumor spread or seeding, Dr. Gardner will explore current solutions. Finally, this talk will aim to understand research needs for skull base disease research, such as increasing collected tissue volume and preservation, strengthening collaboration between surgeons and researchers.

Genomics in Chordoma: Implications for Medical Therapeutics

With increasing urgency, there is a present day need for standardized tissue collection resulting in preserved biological and molecular architecture. Exploring the current standard of care for chordoma patients, this webinar will explore a novel method for obtaining high yield tissue for genomic sequencing. Dr. Ahluwalia presents new thinking on the implications of improving tissue collection for genomic research and advances in therapeutics and launch a discussion into the future of clinical trials for chordoma research.

Minimally Invasive Parafascicular Surgery (MIPS) – Research Updates Recording

Preliminary and proof of concept research focused on optimizing MIPS was conducted at three different academic institutions. This research includes better understanding of subcortical anatomy and corridors, development of new technologies to improve the safety and efficacy of subcortical surgery, and better understanding of the clinical outcomes associated with MIPS.

The SSG awarded close to $30,000 in funding at the 2019 Annual Meeting. Listen to this one-hour webinar to learn about the results from these exciting studies.

• Intraoperative DTI Tractography – Adjusting for Shift during MIPS and Other Neurosurgical Procedures
  Michael Chicoine, MD: Washington University School of Medicine
• Characterizing the Immune Microenvironment Within and Surrounding Nontraumatic Intracerebral Hemorrhage
  Balint Otvos, MD: Cleveland Clinic
• Developing an Operative Simulation for Training Neurosurgeons in Minimally Invasive Surgery
  Daniel Cleary, MD, PhD: UC San Diego

Evidence & Case Reviews from a Multicenter Perspective – Panel Discussion Recording

Surgical techniques are continually evolving to enhance efficiency for surgeons while improving safety and efficacy for their patients. As a result of the delicate nature of neurosurgery, changes to traditional methods of intervention is heavily reliant on clinical outcomes produced by leaders in the field and replicated across multiple institutions in published literature.

This program is an active discussion of evolutionary operative techniques, reproducible outcomes, operative challenges and key learnings in minimally disruptive surgery for subcortical abnormalities.

The session is moderated by Zach Litvack, MD (Swedish Neuroscience Institute). Panel members include: Kaisorn Chaichana, MD (Mayo Clinic, Jacksonville); Rohan Ramakrishna, MD (Weill Cornell); Brad Zacharia, MD (Penn State) and Bobby Starke, MD (University of Miami).

VIRTUAL Connectomics Course Recording

Connectomics is the use of machine learning to make sense of brain connectivity data and has enormous potential in improving our understanding of patients with neurologic disease. 

Michael Sughrue, MD is at neurosurgeon at Prince of Wales Hospital.  Dr. Sughrue partnered with the SSG to facilitate an introduction to connectomic anatomy and imaging virtual course.  During the course, he reviewed the anatomy of the connectome, utilized connectomic software to improve neurosurgical planning, and used connectomics to address functional considerations and neurorehabilitation.